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It is involved in mitochondrial oxidative phosphorylation, indirectly regulates extra-mitochondrial metabolic pathways, and protects cells against excessive ROS generation (90)

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A few of the molecules referenced do have FDA-approved products for specific indications (for example, semaglutide and tirzepatide for type 2 diabetes and chronic weight management, pentosan polysulfate sodium as ELMIRON for interstitial cystitis, and tesamorelin as Egrifta), though their use in this context may still be off-label or compounded