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+ B12 injections suit vegetarians and vegans who do not eat animal foods, patients with confirmed absorption issues such as pernicious anaemia, coeliac disease or significant IBS, older adults whose stomach acid has dropped with age, and patients on long-term metformin or proton-pump inhibitors that lower B12 absorption

Although peripheral and central enterostatin administration decreases dietary fat intake in animals (while enterostatin-receptor antagonists did the opposite) (186), its administration to humans has shown no effects on food intake, appetite, energy expenditure, or body weight (187)

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Those following a vegan or strict vegetarian lifestyle are at greater risk of deficiency and may benefit from regular B12 supplementation or injections