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LAMPs were originally believed just to be structural proteins that protect lysosomal membrane from resident hydrolytic enzymes, although evidence now reveals that they have a key physiological role in suppressing proton leak through TMEM175 channels to facilitate re-acidification when lysosomal pH rises inappropriately 96

Flavonoids increase the serum levels of FSH, and sharply decrease the serum levels of LH, testosterone and insulin in the PCOS-insulin resistant rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and down-regulating the suppressor of cytokine signalling 3 (SOCS3) expression in ovaries of PCOS rats (106)

381 Surprisingly, statins can decrease the levels of mevalonate-5-phosphate and prevent mutated p53 from binding to HSPs, thus promoting the degradation of structural p53 mutants by MDM2 or CHIP E3

Rahman, I

They have a conserved 'sandwich-like' three-dimensional domain with four layers of folds (23)

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