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The inducer of TGF- gene transcription could be activator protein 2 (AP2), whose expression and transcriptional activity at the TGF- promoter is increased in the secondary hyperparathyroidism of CKD (169)

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Clinically reportable genetic changes can frequently be found in patients with apparently sporadic disease

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The multifaceted role of mitochondria in -cells encompasses pivotal processes and pathways, including mitochondrial bioenergetics and metabolism, proton leak, calcium (Ca 2+ ), structural integrity, dynamics, as well as turnover/mitophagy