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CypD knockout (KO) in elderly mice showed better anti-aging effects, such as inhibition of mitochondrial swelling and a higher NAD+/NADH ratio, but further exploration is needed to explain the exact mechanism in heart tissue [38]

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The c-type heme in cytochrome c, a small highly conserved protein of only about 12 kDa, has histidine as the fifth coordination site ligand to the iron atom and methionine as the sixth

The translation pipeline (Figure 3) typically progresses from identifying a promising metabolite or herbal formula, demonstrating efficacy in cellular and animal models, ensuring quality control in formulation, conducting early-phase human safety studies, then larger efficacy trials, and finally seeking guideline inclusion if successful

Knockdown of miR-124 reduces depression-like behavior by targeting CREB1 and BDNF

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