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It is suggested that the synergistic effects of the Ac-G combined treatments in CAA result from their impact on protecting the SOD enzyme and reducing the oxidative stress-induced depletion in cellular GSH levels, where the two Ac-G combination ratios of 8:1 and 4:1 [(1 + 0.125) and (1 + 0.25) g/mL] were significantly more effective in preserving the SOD enzyme activity and reducing GSH depletion when compared to the corresponding gingerol treatments

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have questioned the brain availability of bumetanide due to its low permeability of brain-blood barrier (BBB) and rapid efflux 52

The Journal of Biological Chemistry 284(51):3597335986

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