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Pesticides can disturb oxidative homeostasis through direct or indirect pathways, including mitochondrial or extramitochondrial production of free radicals, thiol oxidation, and depletion of cellular antioxidant reservoirs

It has been demonstrated that eryptosis might alter cell volume, shape, granularity of erythrocytes, as well as modify the phospholipid composition of both inner and outer leaflets of phospholipid bilayers in the cell membrane, leading primarily to PS externalization [85, 86]

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The results provide deeper insights into how mitochondrial dysfunction interacts with non-mitochondrial pathways to drive the systemic manifestations of hEDS

37 Whether diverticulosis results from or causes inflammation and whether progression to diverticulitis likewise results from or causes inflammation is an open question

160 Despite their lack of FDA approval for fibromyalgia treatment, oral cyclobenzaprine (Flexeril, a skeletal muscle relaxant) and amitriptyline (a tricyclic antidepressant) are widely prescribed for fibromyalgia