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These alterations weaken the bloodbrain barrier, allowing systemic inflammatory mediators already elevated in COPD, particularly IL-1, IL-6, CRP, and TNF-, to enter the CNS and perpetuate glial activation [33, 55]

JAMA 329 , 1934 (2023)

Hankey Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh, Bangladesh Md Abdul Hannan Department of Anatomy, Dongguk University, Gyeongju, South Korea Md Abdul Hannan Department of Population Science and Human Resource Development, University of Rajshahi, Rajshahi, Bangladesh Md Nuruzzaman Haque, Md Rafiqul Islam & Mosiur Rahman Medical Research Unit, Universitas Syiah Kuala (Syiah Kuala University), Banda Aceh, Indonesia Harapan Harapan Department of Dental Public Health, Universitas Airlangga (Airlangga University), Surabaya, Indonesia Ninuk Hariyani Australian Research Centre for Population Oral Health, University of Adelaide, Adelaide, SA, Australia Ninuk Hariyani Research Unit, University of Barcelona, Barcelona, Spain Josep Maria Haro Biomedical Research Networking Center for Mental Health Network (CiberSAM), Barcelona, Spain Josep Maria Haro Department of Nursing, Arak University of Medical Sciences, Arak, Iran Mehdi Harorani Sekolah Tinggi Ilmu Kesehatan Indonesia Maju (Indonesian Advanced College of Health Sciences), Institution of Public Health Sciences, Jakarta, Indonesia Risky Kusuma Hartono Department of Zoology and Entomology, Al Azhar University, Cairo, Egypt Ahmed I

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Viruses 13 , 90 (2021)