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Rating: 4.585 (13 reviews)

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burgdorferi lacks genes encoding enzymes necessary for nucleic acid, amino acid, and fatty acid biosynthesis

ZNRF3 is a transmembrane E3 ubiquitin ligase that inhibits endogenous Wnt-mediated activation of the -catenin signaling pathway (Hao et al., 2012)

Similarly, the stem cell factor SOX2 directly binds and activates the SLC7A11 promoter to confer ferroptosis resistance in lung cancer stem cells, which can be abrogated by SOX2 oxidation at Cys265 [31]