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This metabolic shift occurs due to the peptides action on the nicotinamide methylation pathway , which increases intracellular NAD+ availability, facilitating greater oxidative metabolism

Structural Type: Linear peptide fragment (C-terminal fragment of hGH)

doi:10.15605/jafes.037.02.14

Moreover, the discovery of ghrelin O-acyltransferase (GOAT) as the enzyme that catalyzes ghrelin octanoylation, revealed several therapeutic possibilities including the design of drugs that inhibit GOAT and block the attachment of the octanoyl group to the ghrelin third serine residue

This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.