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Mutant APP and Amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimers disease

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This method is useful not only for diagnosis but also for tracking disease progression and evaluating the efficacy of iron-targeted therapies

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Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J and Ganesan AK