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In the very early stages, microglial nodules are seen without lymphocytic infiltration (Singh et al., 2013) suggesting that these innate immune cells were reacting to a subtle early pathology that predated the arrival of T or B cells

Specifically, outreach to child welfare agencies, police departments, juvenile detention facilities, healthcare systems, congregations, youth-serving agencies, and schools or school districts was viewed as essential to increasing the identification of victims

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This immune system reaction can lead to temporary swelling, soreness, and discomfort at the injection site

Infection could bring about an inflammatory response or directly infect the repair tissue, compromising viability and functional maturation of implanted constructs