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Force analysis The magnetic bead possesses the capability of becoming magnetized through the generation of a magnetic moment (where M ) when a magnetic field ( b ) is applied

To further characterize this mechanism, we coupled deep mutational scanning (DMS) of CRBN to a fluorescence-activated cell sorting (FACS)-based assessment of ENL degradation in the presence of rac -dHTC1 or the ENL PROTAC, SR-1114 (Extended Data Fig

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Notably, the vaccine exhibits enhanced immunogenicity against four key serotypes (19F, 19A, 7F, and 3), which are responsible for the heaviest disease burden of pneumococcal infections among children in China