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They represent what rigorous clinical development looks like: Phase I through Phase III trials, post-marketing surveillance, and manufacturer accountability

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Excessive copper binds selectively to lipoylated proteins involved in the tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and cell death by increasing ROS [170, 171]

Nitroblue tetrazolium reduction

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62,63 Excess iron is stored in unstable iron pools, which can increase due to metabolic imbalance, leading to increased ROS production through Fenton reactions