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The Wnt--catenin pathway is pivotal for intestinal cell specification, enabling Wnt proteins, mostly secreted by mesenchymal and Paneth cells, to trigger signaling in neighboring cells 17

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Emodin decreases GSH content, xCT and GPX4 expression, increases ROS generation, MDA, and lipid peroxidation, effects reversed by ferroptosis inhibitors and autophagy inhibitors, iron chelator DFO, ferostatin-1, and NCOA4 silencing

Liebl, S

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