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doi: 10.1155/2017/6405278, 131

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Moderate exercise maintains ROS at normal physiological levels, where ROS act as key signaling molecules to activate the Nrf2 pathway and upregulate the expression of endogenous antioxidants such as HO-1, SOD, and GPx (Merry and Ristow, 2016)

Alterations in the levels of iron, ferritin and other trace metals in Parkinsons disease and other neurodegenerative diseases affecting the basal ganglia

TFRC permits access to ferritin-bound iron for cellular use (ferritinophagy), in a process that allows iron release from ferritin and conversion of ferric iron (Fe 3+ ) to bioactive ferrous iron (Fe 2+ )

3 If the product of a Phase I reaction is not soluble enough to be excreted, a Phase II conjugation reaction will typically accomplish this