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If levels don't respond to standard supplementation, investigate possible MTHFR polymorphisms, malabsorption conditions like celiac or Crohn's disease, or potential medication interactions

While Vitamin B12 is crucial for overall health, it does not directly detoxify the body

doi:10.1016/j.hoc.2016.03.002

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Even the simple calf-stretching maneuver (described in the first paragraph of the section on treatment), if held for 10 to 15 seconds and repeated two or three times just before going to bed, can be a great help in preventing nocturnal leg cramps