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12 week-old mice) ( Paracellular transport across the epithelial barrier is regulated by tight junction proteins, which form cell-to-cell complexes and depend on calcium for assembly ( Cldn3, Ocln, Tjp1 (ZO-1), and Jam1 in the small intestine is lower in newborns (1 day and 2-week-old mice), while the expression of Cldn2 is higher compared to adults (12-week-old mice) ( Intestinal alkaline phosphates is a brush border enzyme expressed and secreted by enterocytes ( in vit ro ( in vivo (24)

13 Vaginal dryness and vulvovaginal atrophy (thinning and weakening) are the most common symptoms reported by postmenopausal women and is the main feature of genitourinary syndrome of menopause

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10.1016/j.ijpharm.2020.120120 19

For injectable forms, a suggested dosage is 0.2 mL delivered subcutaneously once per day

(rubiaceae) inferred from molecular (its, rbcl, and trnt-f) and morphological data