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The main contraindication for using the peptide is existing cancer diseases

We showed that norepinephrine (NE, 50 M) or dopamine (DA, 50 M) exerted potent protective effect against glutamate-induced cytotoxicity, but this effect was not observed when other neurotransmitters such as histamine, -aminobutyric acid, serotonin, glycine and acetylcholine were tested

however, it does not participate in the initial occurrence of the morphology (Fan et al., 2013)

Peri-lesional injection requires precise anatomical knowledge and a higher technical skill level, and the marginal benefit over subcutaneous delivery is not clearly established

Mol Aspects Med 63:1829

3i), suggestive of a role for de novo gene expression