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A 43-year-old man with epilepsy who had been treated with valproic acid (Depakote) (VPA) for 13 years and had a history of multiple suicide attempts and alcohol dependence, presented after ingesting an overdose of VPA and ibuprofen

Furthermore, the narrow therapeutic range of AEDs can result in adverse effects, including affective disorders, cognitive impairment, hepatotoxicity, and recurrent seizures (Tome et al., 2010)

Non-injectable forms remain available

Anti-inflammatory treatments, such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, can help reduce leukocyte activation and ROS production

1-Methylhistidine, ornithine, proline, hydroxyisocaproic acid, N-acetylglutamine and phenylacetylglutamine were elevated in SC which added further evidence for amino acid imbalances in ME/CFS

eLife 10 , e56519 (2021)