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Immune checkpoint inhibitors (ICIs), such as monoclonal antibodies targeting programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have shown promise in CRC treatment ( Despite these advancements, CRC outcomes remain suboptimal

As indicated by the current results, the changes in various indicators with the sole use of CAF are quite limited

Binds only the growth hormone receptor (no prolactin, ACTH, or appetite effects)

Some of the most important hormones for controlling hunger are neuropeptide Y (Npy), cholecystokinin (Cck), peptide YY (Pyy), and cocaine and amphetamine-regulated transcription factor (Cart) (Rnnestad et al., 2017)

At present, even in the same type of tumor, different tumor subtypes may have different requirements for BCAAs metabolism and regulatory signaling pathways