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Figure 2 In the late 1990s Taisho Pharmaceuticals filed patent applications covering compounds that according to competitive experiments with radiolabeled [ 125 I]Ang IV exhibited high affinity to hippocampus membranes from guinea pig (Kobori et al., 1997

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Silencing of NRF2 reduces the expression of ALDH1A1 and ALDH3A1 and sensitizes to 5-FU in pancreatic cancer cells

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Subsequent studies confirmed that Epithalon-treated cell cultures exhibited longer telomeres and significantly greater cell division capacity compared to untreated controls, with implications for research into cellular senescence mechanisms