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In specific embodiments, D is selected from the group consisting of antimetabolites, (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), ablating agents (e.g., mechlorethamine, thioepa chloraxnbucil, meiphalan, carmustine (BSNU) and lomustine (CCNU), cyclothosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin)), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine)

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After 4 weeks, the treatment groups MMSE scores didnt improve more from baseline than did the placebo groups

Examples include predicting monounsaturated fatty acid-mediated radioresistance risk by detecting ACSL3/4 expression levels (197, 199), and optimizing ferroptosis induction strategies for NSCLC patients using TRIM3-SLC7A11 ubiquitination degradation markers (200)

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