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doi: 10.1080/19420862.2017.1304869 Summary Keywords immunogenicity, AMG 966, inflammatory bowel disease, anti-drug antibodies, TNF, TL1A, tolerance, immune complexes Citation Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF-S, Teixeira dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S and Mytych DT (2021) Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target

31 Researchers have demonstrated that disorganizing the nucleotides of the seed region without changing the 2-OMe, 2-F or PS content or placing a GNA at position 7 of the siRNA antisense strand can markedly alleviate off-target effects and mitigate hepatotoxicity because these modifications affect the binding of siRNA with undesired target mRNA in a seed region-specific manner

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