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However, because they cost to construct and operate, their upscale has not been achieved (Costa et al

Hussain TM, Chandrasekhar T, Hazara M, Sultan Z, Saleh BK, Gopal GR

a commercial product called PROFIN) in a single-center, double-blind, randomized, placebo-controlled study in 72 healthy women (4065 years of age) with moderate eye wrinkles who met the study criteria [45]