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ECG Recording In deeply anesthetized rats, an ECG was recorded continuously in all three main leads by positioning stainless steel electrodes on all four limbs using an ECG monitor by 2090 Medtronic programmer (Minneapolis, MN, USA) connected to a digital oscilloscope LeCroywaverunnerLT342 (Chestnut Ridge, NY, USA), which enabled precise recordings, measurements and analysis of ECG parameters

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Some patients may require injections weekly, while others may only need them monthly or as needed

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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

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3 The peripheral nociceptive sensory neurons in degenerated IVDs 1 suggest a predominant role of nerve innervation in the development and maintenance of discogenic pain

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Taken together, this study found that at a 3 week timepoint, cuprizone pellets were more efficacious than cuprizone powder at producing astrocyte reactivity, microglial activation, oxidative stress, tissue swelling, and a reduction in the density of mature oligodendrocytes and demyelination when compared to control feeds, particularly in the caudal corpus callosum

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