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However, by the time a person reaches their forties, this time window has shrunk to 45 days and diminishes with age

doi: 10.1016/j.molcel.2017.04.027 188 SakumaM.AkahiraJ.SuzukiT.InoueS.ItoK.MoriyaT.et al

Currently, most of the studies had focused on specific immune cells, pathogen recognition receptors and cytokines independently, which have yielded varying results and failed to depict the precise role of innate immune dysfunction in the pathophysiology of IBS

Recent ISAPP-oriented quick guides and professional tools seek to translate these criteria into clinical and regulatory practice for healthcare professionals and industry (521, 522)