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Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells

This suggests that contacts outside of the ligand-binding site contribute to its improved affinity in the presence of ENL and, indeed, our model revealed an extensive interfacial interaction between CRBN and ENL YEATS, with a buried solvent-accessible surface area of ~2,258 2 and a high degree of shape complementarity (0.64 out of 1) 52

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Pichon MM, Drelinkiewicz D, Lozano D, et al