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Excitotoxicity causes massive calcium influx, activating calcium-dependent proteases and NOS, which rapidly trigger MMP-9 activation, leading to the swift degradation of tight junctions and the basement membrane (166)

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Instead, it reflects a broader collapse of ubiquitin-centered regulatory networks that integrate proteostasis, signaling, inflammation, and neuronal function

By contrast, uridine supplementation significantly rescued these phenotypes in aged oocytes (Fig

Gonzales E, Taylor SA, Davit-Spraul A, Thbaut A, Thomassin N, Guettier C, Whitington PF, Jacquemin E

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