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The distance between blood vessels and cells, which is maintained in a normal microenvironment, becomes disrupted within the TME

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The formation of glutathione conjugates is catalyzed by glutathione-S-transferases (GSH)

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G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes

Shorter telomeres are associated with aging and with several age-related disease states, but telomere biology is not a single on-off switch for longevity