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These nutritional disorders augment the level of Homocysteine in the blood, leading to hyperhomocysteinemia, which may play a role in the pathogenesis of PD

Histamine N-methyltransferase (HNMT) is the enzyme responsible for metabolizing histamine that is released by immune cells

Nat Biotechnol 48:5365

Iron exposure amplifies these effects, especially in the mutant, which exhibits altered representation of functions like amino acid and nucleotide metabolism

This article summarizes recent studies about the mechanisms and biomarkers of oxidative stress

These studies confirmed that GABA release is dependent on the entry of extracellular Ca 2+ through voltage-gated channels and not by membrane depolarization itself