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Setting up a precise mechanistic model of co-cultures will contribute to better controllability and stability in multi-species processes and enable upscaling and exploitation for biotechnological applications

Recently, a three-fold increase in plasma and organ lipid peroxides has been noted in SHROB relative to lean SHR littermates (Ernsberger, Theodorou, Edwards, & Koletsky, 2008)

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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells

It can spread more readily to distant sites in the body, like the lungs

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