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Studies have showed that cancer cells preferentially use glycolysis to rapidly generate ATP for cell growth and proliferation even under the condition with sufficient oxygen, which is known as Warburg effect

Brabletz, T

10.3390/nu15051107 5 Aguilar-ZrateP.CruzM

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found that BPTES at concentrations of 20 M and 40 M not only reduced the oxygen consumption and oxidative phosphorylation capacity, but also suppressed TCA cycle by inhibiting cellular glutamine metabolism, leading to the inhibition of cell growth and proliferation in leukemic cell lines with BCR- ABL mutations [65]