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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

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2 Review of the peripheral blood smear is a critical step in the evaluation of any anemia

This is the simplest option and mirrors what you would get from brand-name products (minus the FDA approval pathway)

However, further translational research is required to determine its full mechanistic scope and potential therapeutic applications

[DOI] [PMC free article] [PubMed] [Google Scholar] Kalilani L, Friesen D, Boudiaf N, Asgharnejad M