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The discovered CBM does not require a negative charge at position +5, described to be essential in mammals, but the presence of an aspartic acid at position +3, which mediates interactions with the positively charged residues at the NTD binding sites

Electrophoresis 18 , 27142723 (1997)

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The density for this water was weaker than that of the ligand, although strong enough to warrant modelling (Supplementary Fig

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