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10.1038/mp.2013.83 65 WeiJ.ZhangY.-Y.LuoJ.WangJ.-Q.ZhouY.-X.MiaoH.-H.et al (2017)

The non-DAC variant (as in this blend) has an extended half-life relative to native GHRH but shorter than CJC-1295 with the Drug Affinity Complex (DAC) modification Ipamorelin a synthetic compound studied as an agonist of the growth hormone secretagogue receptor (GHS-R1a, the ghrelin receptor) a distinct receptor on the same somatotrope cell population, downstream of different intracellular signaling cascades than GHRHR Published research investigates the combinatorial effect of dual-receptor agonism on somatotrope GH-release kinetics in cultured cell models and in-vivo rodent preparations

10.1016/j.ceb.2004.06.012 28 Lafita-NavarroM

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Further clinical investigation into this synergistic strategy is warranted to assess efficacy and establish evidence-based guidelines for its use in integrative oncology

Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and retroviral-mediated disorders in warm-blooded mammals