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Modern formulations using reduced L-glutathione have addressed earlier concerns about absorption

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You should not take Imigran if you: Are allergic to sumatriptan Have heart disease such as angina or a history of heart attack Have circulation problems in your legs (peripheral vascular disease) Have had a stroke or transient ischaemic attack (TIA) Have uncontrolled high blood pressure Have severe liver disease Are taking medicines containing ergotamine or similar medicines such as methysergide Are taking other triptans (5-HT1 receptor agonists) Are taking MAOIs or have taken them in the last 2 weeks If you are pregnant, speak to a healthcare professional before using Imigran

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To develop such therapies, a deeper understanding of both disease pathogenesis and mechanisms of barrier regulation must be reached