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discovered that myoferlin targeting with the pharmaceutical drug WJ460 caused mitophagy and ROS accumulation, leading to lipid peroxidation and cell death independent of apoptosis [57]

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Tentatively, the results on light to medium skin tones can be observed within 1-3 months, within 3-6 months on darker skin tones, within 6-12 months on very dark skin tones, and within 18 months and above for even darker skin tones

It was suggested that in the absence of redox metals, A is nontoxic, and the aggregation of A requires the participation of metals (Li et al., 2013

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