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Description

As a tripeptide composed of glutamate, cysteine, and glycine, it functions as the primary thiol-based redox buffer, neutralizing reactive oxygen species (ROS), supporting Phase II detoxification pathways, and facilitating the excretion of xenobiotics and heavy metals [1] [8]

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Disclosures: Alejandra Paredes-Marin: Nothing to Disclose, Julia Napoli: Nothing to Disclose, Vikram Sivakumar: Nothing to Disclose, Christian Near: Nothing to Disclose, Dakota Trick: Nothing to Disclose, Helen Adams: Nothing to Disclose, Alyson Harty: Nothing to Disclose, Ritu Agarwal: Nothing to Disclose, Douglas Dieterich: Gilead: Consultant, madrigal: Speaking and Teaching, John Bucuvalas: Mirum Pharmaceutical: consultant, Madrigal Pharmaceutical: Consultant, Neurogene: Consultant, Iecure: Consultant, Tatyana Kushner: Gilead: Grant/Research Support, Gilead: Advisor, GSK: Advisor, Eiger: Advisor, Jaime Chu: Albireo: Consultant, Swati Antala: Nothing to Disclose, Asher Leviton: Nothing to Disclose, Augusto Villanueva: Nothing to Disclose, Scott Friedman: 89 Bio: Consultant, Boehringer Ingelheim: Consultant, Boston Pharmaceutical: Consultant, Bristol Myers Squibb: Consultant, Merck: Consultant, Glycotest: Consultant, Morphic Therapeutics: Consultant, HepGene: Consultant, North Sea Therapeutics: Consultant, Pfizer Pharmaceuticals: Consultant, Sagimet: Consultant, Scholar Rock: Consultant, Prosciento: Consultant, Seal Rock: Consultant, Surrozen: Consultant, Takeda Pharmaceuticals: Consultant, Rachel Smith: Nothing to Disclose, Xiaotao Zhang: Nothing to Disclose, Meena Bansal: Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose, Nothing to Disclose 1189 CLINICAL, PSYCHOSOCIAL AND SOCIAL DETERMINANTS OF HEALTH FACTORS ASSOCIATED WITH DEGREE OF HEPATIC STEATOSIS AND LIVER STIFFNESS AMONG OVERWEIGHT AND OBESE ADULTS AT RISK OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE Monica Tincopa 1 Lisa Richards 1 Rohit Loomba 1 , 1 University of California, San Diego Background: The severity of metabolic dysfunction-associated steatotic liver disease (MASLD) among patients with overweight and obesity is heterogeneous and may be moderated by behavioral, psychosocial and social determinant of health (SDOH) factors

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