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Additionally, they influence fibroblast behavior by enhancing proliferation, migration, and adhesion while inhibiting apoptosis-related pathways involving Bax, Bcl-2, caspase-3, and caspase-9

Studies have shown that senolytics which target p53 are associated with enhanced health results in older mice (van Deursen 2019

Kim, S., Shin, J

[DOI] [PubMed] [Google Scholar] 12.Bates CJ, Pentieva KD, Prentice A

Progetto MARGHERITARapporto 2007 Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva (GIVITI)

Moreover, DEX treatment (0.5 g/kg/h, pumping injection, before induction of anesthesia to the end of surgery) has been reported to reduce cardiac troponin I and MDA levels and to decrease the incidence of arrhythmias in patients undergoing cardiac valve replacement [234, 235]