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The growing body of evidence from in vivo research indicates that nanoparticles based siRNA therapies have proven effective as targeted AD therapeutics (99)

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doi:10.1016/j.curtheres.2017.10.004 Luthuli S, Wu S, Cheng Y, Zheng X, Wu M, Tong H

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However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18

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