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This study demonstrates several notable strengths

As the aetiology of sarcoidosis is unknown, no specific treatment and no pathognomic markers exist

383 In patients with major depression and a genetic mutation that causes disruption in homocysteine metabolism, taking a multivitamin-mineral supplement with the metabolized forms of B vitamins reduced homocysteine levels and was more effective than placebo at reducing depression symptoms, resulting in a 42% remission rate after eight weeks

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