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By contrast, extracranial metastases arise in tissues with abundant lymphatic drainage and ongoing immune system influence, which allows for antigen presentation and T-cell priming

We thank Zhe-Sheng (Jason) Chen, (MD., Ph

Thus, mitophagy induced by hypoxia is an adaptive metabolic response that prevents increased ROS and cell death (Zhang et al., 2008)

The authors show that HIF-1 binds to hypoxia response elements (HREs) in the promoters of several glycolytic genes, including aldolase A , enolase 1 , and lactate dehydrogenase A (LDHA), leading to increased gene transcription (64)

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Friedman BJ, et al