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1 Introduction Malignant melanotic nerve sheath tumors (MMNSTs), previously referred to as melanotic schwannomas (MS), are exceptionally rare neoplasms accounting for less than 1% of primary peripheral nerve sheath tumors ( For localized MMNST, treatment typically involves surgical resection (gross-total resection [GTR] or subtotal resection [STR]) combined with adjuvant radiotherapy ( VEGFR1/2/3 , c-Kit , PDGFR- , and FGFR , thereby disrupting tumor growth and survival signaling pathways ( 2 Case description A 54-year-old female presented with a right neck mass without other associated symptoms

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Thus, PKC activated by Phorbol-12-myristate-13-acetate (PMA) catalyzes the phosphorylation of TGF, Amphiregulin and HB-EGF precursors facilitating their shedding mediated by ADAM17 and releasing the soluble growth factor outside the cell (Watanabe et al., 1992