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These findings further confirm that redox collapse and oxidative stress play a central role in ferroptosis induced by the combined treatment

Adult conditional knockout of PGC-1 leads to loss of dopamine neurons

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In the enteric system, 90% of total tryptophan is produced via the kynurenine pathway, which also generates kynurenic and quinolinic acids that are essential for the operation of the enteric and central nervous systems, respectively (Gheorghe et al., 2019)