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Moreover, an in vivo study with supplementation with 40 mg/kg per day in C57BL/6 mice of lycopene shows an increase in the CD4+/CD8+ T-cell ratio and in the percentages of IFN+, perforin+, and granzyme B+ expression on CD8+ T cells and an enhanced apoptosis in tumor cells with combined lycopene and anti-PD-1 treatment in comparison with those of either lycopene or anti-PD-1 alone [59]

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M., Kandemir, H., Shah, S