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These molecules transfer from the cytoplasm to the nucleus and activate many transcription factors, such as NF-kappaB (NF- B) and activator protein-1 (AP-1), which can promote the release of various molecules, including p16, p21, IL-6 and interlukin-18 (IL-8)

The % release has reduced to 59% in ex-vivo from 79 % in-vitro

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2009 Nov;119(11):3384-94

Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile-An Overlooked In Vitro Mechanism of Protection

Figure 2 4.1 Strategies targeting the glycolytic pathway 4.1.1 Inhibitors of key glycolytic enzymes Targeting core enzymes of the glycolytic pathway is a direct strategy to intervene in this metabolic axis