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Conditions associated with elevated B12 levels include: Liver disease : Hepatocellular damage releases stored B12 into circulation, with levels correlating with disease severity in conditions such as cirrhosis, hepatitis, and hepatocellular carcinoma Renal impairment : Reduced kidney function decreases B12 clearance, leading to accumulation Haematological malignancies : Myeloproliferative disorders, acute leukaemia, and polycythaemia vera can elevate B12 through increased production of B12-binding proteins (transcobalamins) Solid tumours : Certain cancers, particularly those affecting the liver or gastrointestinal tract, may elevate B12 levels A specific concern relates to cyanocobalamin in patients with Leber's hereditary optic neuropathy , a rare mitochondrial disorder

B12 is needed for mitochondrial energy production, and for detoxification

It builds the capillary network active regeneration depends on (new blood vessel formation) and stabilizes tissue barriers so new tissue holds together. Without blood flow to the dermis, GHK-Cu has the signal but the raw material never reaches the work

Vitamin B12, also known as cobalamin, is a water-soluble vitamin critical to metabolism, nervous system health, and red blood cell formation

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Given possible side effects and interactions, patients should speak to their gastroenterologist about the benefits and limitations of CAM before using any type of CAM therapy