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The data were analyzed with MultiQuant v3.0.3 software (Sciex, Darmstadt, Germany)

Cellular senescence: from mechanisms to current biomarkers and senotherapies

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In addition, androgens promote lipolysis and glucose uptake by upregulating the expression of key enzymes and proteins involved in glucose and lipid metabolism, such as ATGL and GLUT4, to alleviate glycolipotoxicity, thus eventually achieving a protective effect on the structural integrity and function of the electron transfer chain ( Figure 2 )