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REJUVENATING & REFRESHING

Aquaculture 598:742026

A shift in cellular composition could masquerade as a pathway down-regulation

doi: 10.1016/j.jstrokecerebrovasdis.2024.108107 196

Fe 3+ forms a complex (holo-Tf) with transferrin (Tf) after entering the blood circulation, and binds to TfR1 on the surface of brain microvascular endothelial cells (BMECs), and then the Fe 3+ -containing TfTfR1 complex enters the BME through clathrin-mediated endocytosis (Pardridge et al